Reconcile or Clomicalm - what's the difference?

Different drug classes. Reconcile (fluoxetine, SSRI) is generally first-line; Clomicalm (clomipramine, TCA) is used where SSRIs are unsuitable or have not worked.

Does Clomicalm cure separation anxiety?

No medication does on its own. Behaviour modification is essential alongside.

Clomicalm price comparison UK

Tricyclic antidepressant licensed for separation-related disorders in dogs. Older than Reconcile, still widely prescribed. Active ingredient: clomipramine. Below: compare UK vet prices with VMD-approved online pharmacies for your dog's weight.

Dog weight (kg)Your vet's price per month (optional, £)

Typical vet price

£30.00–£42.00/mo

indicative UK range

Cheapest online

no data

Annual saving

—

after £21 prescription fee: £0.00–£0.00

Based on a 15 kg dog, recommended strength: 5 mg. Assumes 12 months of continuous use (chronic dosing) and one written prescription per year. CMA Order caps the prescription fee at £21 for the first medicine, plus £12.50 per additional medicine on the same prescription. Prices are indicative and last verified 2026-05-15. Always confirm the current price on the pharmacy site before purchase.

No online price data yet for Clomicalm at this strength. We are building the database - check back soon.

What Clomicalm treats

Tricyclic antidepressant licensed for separation-related disorders in dogs. Older than Reconcile, still widely prescribed.

Why it costs more at the vet

Elanco-branded; same dispensing-margin pattern as other branded behavioural products.

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Email template, prescription steps and refill setup — the full path from "I just paid too much at the vet" to "I'm saving £X every month".

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How to get a written prescription

The CMA Order is legally binding by 23 September 2026. Every UK vet must offer a written prescription on request, with the fee capped at £21 for the first medicine plus £12.5 per additional medicine on the same prescription. Take the prescription to any VMD-approved online pharmacy listed above. We have a short guide with a template email you can send to your practice.

Read the full prescription guide →

Common side effects

Sedation
Vomiting
Dry mouth

This is not a complete list. Always read the patient information leaflet and speak to your vet about side effects.

FAQ

Reconcile or Clomicalm - what's the difference?: Different drug classes. Reconcile (fluoxetine, SSRI) is generally first-line; Clomicalm (clomipramine, TCA) is used where SSRIs are unsuitable or have not worked.
Does Clomicalm cure separation anxiety?: No medication does on its own. Behaviour modification is essential alongside.

Related medications

Behaviour

Reconcile

SSRI antidepressant licensed for separation-related disorders in dogs, ideally combined with behaviour modification.

Natural calming supplement derived from a milk protein. Not a POM-V medicine - available without prescription. Used for mild stress, travel, kennelling and adjustment periods.

Oromucosal gel for noise-phobia events such as fireworks, thunderstorms or gunshots. Applied to the gum 30-60 minutes before the trigger.

Chronic pain (especially neuropathic) and situational anxiety in dogs.

Track Clomicalm price drops

We'll email when Clomicalm drops in price at any of the pharmacies above.

Pricing data status: indicative. Last verified 2026-05-15. Pharmacies change prices regularly - always confirm before purchase. Not medical advice.