Do I need a prescription for Zylkene?

No - it is a nutraceutical, not POM-V. You can order it directly from any pharmacy or pet retailer.

How long before an event should I start Zylkene?

Start at least 1-2 days before, ideally a week. It is not a same-day calmer like Sileo.

Zylkene price comparison UK

Natural calming supplement derived from a milk protein. Not a POM-V medicine - available without prescription. Used for mild stress, travel, kennelling and adjustment periods. Active ingredient: alpha-casozepine. Below: compare UK vet prices with VMD-approved online pharmacies for your dog's weight.

Dog weight (kg)Your vet's price per month (optional, £)

Typical vet price

£18.00–£26.00/mo

indicative UK range

Cheapest online

£17.95/mo

Pet Drugs Online

Annual saving

£0.60–£96.60

after £21 prescription fee: £0.00–£75.60

Based on a 15 kg dog, recommended strength: 225 mg. Assumes 12 months of continuous use (chronic dosing) and one written prescription per year. CMA Order caps the prescription fee at £21 for the first medicine, plus £12.50 per additional medicine on the same prescription. Prices are indicative and last verified 2026-05-15. Always confirm the current price on the pharmacy site before purchase.

Pharmacy	Pack	Pack price	Monthly cost	Buy
Pet Drugs Online VMD approved · Free over £39	30 capsules	£17.95	£17.95 Best value	Buy from Pet Drugs Online
Animed Direct VMD approved · Free over £29, next-day available	30 capsules	£19.03	£19.03	Buy from Animed Direct
VetUK VMD approved · Free over £29	30 capsules	£20.28	£20.28	Buy from VetUK

What Zylkene treats

Natural calming supplement derived from a milk protein. Not a POM-V medicine - available without prescription. Used for mild stress, travel, kennelling and adjustment periods.

Why it costs more at the vet

Vionate / Vetoquinol product, often sold in clinic at full RRP. Because it is not POM-V you do not need a prescription, but it is still cheaper online.

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Email template, prescription steps and refill setup — the full path from "I just paid too much at the vet" to "I'm saving £X every month".

Open the 5-minute switch guide →

How to get a written prescription

The CMA Order is legally binding by 23 September 2026. Every UK vet must offer a written prescription on request, with the fee capped at £21 for the first medicine plus £12.5 per additional medicine on the same prescription. Take the prescription to any VMD-approved online pharmacy listed above. We have a short guide with a template email you can send to your practice.

Read the full prescription guide →

Common side effects

None significant

This is not a complete list. Always read the patient information leaflet and speak to your vet about side effects.

FAQ

Do I need a prescription for Zylkene?: No - it is a nutraceutical, not POM-V. You can order it directly from any pharmacy or pet retailer.
How long before an event should I start Zylkene?: Start at least 1-2 days before, ideally a week. It is not a same-day calmer like Sileo.

Related medications

Behaviour

Sileo

Oromucosal gel for noise-phobia events such as fireworks, thunderstorms or gunshots. Applied to the gum 30-60 minutes before the trigger.

SSRI antidepressant licensed for separation-related disorders in dogs, ideally combined with behaviour modification.

Tricyclic antidepressant licensed for separation-related disorders in dogs. Older than Reconcile, still widely prescribed.

Track Zylkene price drops

We'll email when Zylkene drops in price at any of the pharmacies above.

Pricing data status: indicative. Last verified 2026-05-15. Pharmacies change prices regularly - always confirm before purchase. Not medical advice.