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Sileo price comparison UK

Oromucosal gel for noise-phobia events such as fireworks, thunderstorms or gunshots. Applied to the gum 30-60 minutes before the trigger. Active ingredient: dexmedetomidine. Below: compare UK vet prices with VMD-approved online pharmacies for your dog's weight.

Typical vet price
£31.00–£45.00/mo
indicative UK range
Cheapest online
£22.50/mo
Pet Drugs Online
Annual saving
£102.00–£270.00
after £21 prescription fee: £81.00–£249.00
Based on a 15 kg dog, recommended strength: 0.1 mg/ml. Assumes 12 months of continuous use (chronic dosing) and one written prescription per year. CMA Order caps the prescription fee at £21 for the first medicine, plus £12.50 per additional medicine on the same prescription. Prices are indicative and last verified 2026-05-15. Always confirm the current price on the pharmacy site before purchase.
PharmacyPackPack priceMonthly costBuy
Pet Drugs Online
VMD approved · Free over £39
1 3 ml syringe (course)£22.50
£22.50
Best value
Buy from Pet Drugs Online
Animed Direct
VMD approved · Free over £29, next-day available
1 3 ml syringe (course)£23.85
£23.85
Buy from Animed Direct
VetUK
VMD approved · Free over £29
1 3 ml syringe (course)£25.42
£25.42
Buy from VetUK

What Sileo treats

Oromucosal gel for noise-phobia events such as fireworks, thunderstorms or gunshots. Applied to the gum 30-60 minutes before the trigger.

Why it costs more at the vet

Highly seasonal stock; vets stockpile pre-firework season and price accordingly. Online stays priced consistently across the year.

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How to get a written prescription

The CMA Order is legally binding by 23 September 2026. Every UK vet must offer a written prescription on request, with the fee capped at £21 for the first medicine plus £12.5 per additional medicine on the same prescription. Take the prescription to any VMD-approved online pharmacy listed above. We have a short guide with a template email you can send to your practice.

Read the full prescription guide →

Common side effects

  • Mild sedation
  • Vomiting (rare)

This is not a complete list. Always read the patient information leaflet and speak to your vet about side effects.

FAQ

How quickly does Sileo work?
Most dogs settle within 30-60 minutes. Effects last 2-3 hours; the dose can be repeated up to 5 times in an event night.
Can I use Sileo every weekend during firework season?
It is intended for situational use. Speak to your vet about a behaviour plan if anxiety is becoming frequent.

Related medications

Track Sileo price drops

We'll email when Sileo drops in price at any of the pharmacies above.

Pricing data status: indicative. Last verified 2026-05-15. Pharmacies change prices regularly - always confirm before purchase. Not medical advice.